Abstract: Organophosphate nerve agents can cause great harm to human health and life, and their detection technology is a research hotspot in recent years. In this work, the Schiff base modified structure TBH and TBH-Zn sensing probes were developed and used for the liquid phase detection of sarin analog diethyl chlorphosphate（DCP）, which showed very low detection limit, as low as 26.6 nM, and showed good selectivity for series organophosphorus interference. Correlation characterization and theoretical calculations show that the metal coordination structure is jointly modulated with the Schiff base structure to construct a higher performance "turn-on" sensitive system. The fluorescence enhancement performance was about 2.5 times that of the TBH probe. The coordination-type fluorescent probe design strategy will be of great value in the design of high-performance sensing system in the future.