Abstract: Flexible and stretchable transistor is one of the most important part of frontier science. Different from the rigid devices, flexible and stretchable devices have advantages including good flexibility and biocompatibility and have been widely applied. In order to ensure the flexibility, all materials need to be flexible and stretchable. In addition, the device need to be comfortable and practicable which means it is necessary to be thinner, and the preparation method of the device also have some special requirements. Here, we summarize the materials and device preparation methods of flexible stretchable field effect transistors in detail, and we believe it could provide a reference for researchers in this area.