Abstract: MIL-101 is a kind of metal-organic frame structure material with high specific surface area and high porosity. Its framework structure does not change under 300 ℃, and it has better structural stability in water, air and organic solvents. It overcomes the shortcomings of poor hydrothermal stability of most MOFs materials, which makes the structure of MIL-101 difficult to collapse in the modification process. Its unique frame structural is beneficial to loading and regulating metal nanoparticles or compounds with excellent catalytic properties, to the transmission of photo-generated electron, and to the modification of functional group. Therefore, MIL-101 has great application potential in the field of photocatalysis. In this review, the synthesis and design methods of MIL-101 are introduced, the existing problems in the application of MIL-101 in photocatalytic hydrogen production and its optimization and modification strategies are summarized, the application prospect of MIL-101 is prospected.