Abstract: Electronic skin is a kind of artificial skin, which simulates the perception ability of human skin through the selection of functional materials and structural design. A new self-powered flexible and wearable hybrid electronic skin system is designed here. The electronic skin system efficiently integrates the triboelectric nanogenerator and piezoelectric nanogenerator to construct a flexible electronic skin system that can sense skin pressure, position and power generation information at the same time. It can realize the real-time signal detection of the sensor and has the power generation function. The power module supplies power to other devices. Using the electrospinning process, a high-dielectric constant PVDF flexible nano-film was prepared to improve the output characteristics of the triboelectric nanogenerator. The overall thickness of the electronic skin is 182 μm, and its stretchability can reach 130% of its own. In its output characteristics, the open circuit voltage is 200 V, and the short circuit current is 8 μA. By collecting the output signal and inputting it into the deep learning module for training, the gesture discrimination is realized. In addition, the linear relationship between mechanical force input and electrical output is used to realize positioning and pain perception functions. Therefore, the electronic skin system can be used for human-computer interaction, signal monitoring and smart sensing. It has broad application prospects in the field of artificial intelligence.