Abstract: Electronic skin is a flexible, stretchable, and multifunctional device that can simulate human perceive functions, which can be used to sense external stimuli, monitor health, and provide pathological feedbacks, has been applied in wearable devices, health monitoring, and medical prosthetics. According to the sensing functions of sensors, i.e., strain sensing, pressure sensing, and temperature sensing, we mainly reviewed the preparation and approaches to adjust sensitivity of flexible sensors based on supramolecular elastomers, and analysis their performances. Finally, this review pointed out the main constraints in the development of flexible sensors based on elastomers, e.g., the limitation of the development of multifunctional flexible sensors, the limited selection of flexible substrates, and conductive fillers. We put forwarded the future research work direction of flexible sensors.