Abstract: Catalytic conversion technology provides an effective method for solving environmental and energy problems caused by rapid economic development. Noble metal catalysts are widely used in various catalytic reaction occasions due to their high catalytic efficiency. However, due to the shortage of precious metal resources and high prices, the development of precious metal catalysts has been restricted. Therefore, the development of high-efficiency, low-cost and stable catalysts has always been the focus of research in the field of precious metal catalysis. Since the preparation of the single-atom catalyst is successful, it has the advantages of high catalytic efficiency, good selectivity, high atom utilization, and low cost. Good progress has been made in the field of precious metal catalysts. Based on the work done by researchers in the direction of single-atom catalysts in recent years, this paper introduces the main preparation methods of single-atom catalysts, reviews the research progress of noble metal single-atom catalysts in fuel cells, and looks forward to its development.